Crystallization-induced diastereomer transformation of 2-quinolone-4-carboxamide followed by stereoselective intermolecular photocycloaddition reaction.
نویسندگان
چکیده
2-Quinolone-4-carboxamide derived from (S)-proline, which exists as a mixture of two diastereomers before crystallization, converged to a single diastereomer by crystallization (CIDT), and the homochirality was transferred by a intermolecular 2 + 2 photocycloaddition reaction with high optical activity.
منابع مشابه
Diastereoselective photocycloaddition using memory effect of molecular chirality controlled by crystallization.
Naphthamides derived from L-proline, which exist as a mixture of several diastereomers in solution, converged to single diastereomer by crystallization, and the conformational transformation was controlled after the crystals were dissolved in the solvent at low temperature, where the frozen conformation was retained long enough for subsequent asymmetric reaction.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 6 5 شماره
صفحات -
تاریخ انتشار 2008